White Button Mushroom Supplements May Help Prevent Progression of Prostate Cancer

In a new study in the field of integrative oncology, researchers are exploring the potential of white button mushroom supplements as part of a holistic approach to cancer treatment. City of Hope, a renowned cancer research and treatment institution, recently published findings that suggest these mushroom-derived supplements could help slow or even prevent prostate cancer from spreading. Their phase 2 clinical trial, focused on “food as medicine,” offers preliminary human data that highlights the potential impact of diet on cancer care.

The study, published in Clinical and Transitional Medicine, found that white button mushroom supplements appear to reduce levels of myeloid-derived suppressor cells (MDSCs) in the body, an immune cell class linked to cancer development and metastasis. “We’re finding that plant-derived substances may one day be used to support traditional cancer treatment and prevention practices,” said Shiuan Chen, PhD, professor and chair of the Department of Cancer Biology and Molecular Medicine at City of Hope. According to Dr. Chen, this work supports the future potential of “food as medicine” as part of evidence-based cancer care for all patients impacted by cancer.

The research team conducted preclinical tests in mouse models and found that white button mushroom extract delayed tumor growth and extended survival. By reducing MDSC levels, the supplement appears to enhance the immune system's T cell response, enabling it to better target and eliminate cancer cells.

Blood analyses from eight men in the trial, all under active surveillance for prostate cancer, showed encouraging changes. After three months of taking white button mushroom supplements, their samples revealed lower levels of MDSCs and increased numbers of anti-tumor T and natural killer cells. According to researchers, this suggests that the supplement could potentially strengthen immune defenses against cancer while slowing the disease's progression.

While these findings indicate promise, researchers caution against using unverified mushroom supplements. “Our study emphasizes the importance of seeking professional guidance to ensure safety and to avoid self-prescribing supplements without consulting a health care provider,” said Dr. Xiaoqiang Wang, PhD, City of Hope scientist and first author of the study. However, Dr. Wang noted that consuming fresh white button mushrooms as part of a regular diet is a safe way to incorporate these potential benefits.

City of Hope’s research into food-based therapies like white button mushrooms, grape seed extract, and berries, reflects a growing recognition of integrative treatments’ value. With continued investigation, these approaches could become additional components of cancer care, offering patients expanded options for prevention and treatment.