Obesity may affect immune system response to coronavirus

Obesity may cause a hyperactive immune system response to the novel coronavirus (COVID-19) infection that makes it difficult to fight off the virus, according to a new case review published in the journal Endocrinology.

In the review, the authors describe the impact of obesity on the immune system. They discuss the irregular immune responses caused by obesity that drive organ injury in severe COVID-19 infection and impair a person's ability to fight the virus.

Obesity not only leads to problems like heart disease and diabetes, but also influences the immune system in many ways, according to the manuscript. Obesity causes a chronic, low grade activation of some parts of the immune system. When someone with this preexisting condition is faced with an infection, this could lead to hyper-activation of the immune system, but in a detrimental way that does not fight infection, the authors said.

“The COVID-19 pandemic has made us aware of the complex interactions of obesity with infectious diseases, and the gaps in our understanding of how chronic health conditions affect our immune responses to acute infection,” said Durga Singer, MD, corresponding author of the University of Michigan in Ann Arbor, Michigan. “Recent evidence has highlighted how one part of the immune system, the macrophage, may be a culprit in driving severe COVID-19 disease. Our manuscript focuses on what is already known about the interaction of obesity, macrophages and other infections like influenza. These findings highlight the importance of understanding how obesity might interact with new drugs or vaccines that are developed for COVID-19.”

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