BPA replacement hinders heart function

Bisphenol S (BPS), a replacement for bisphenol A (BPA), can hinder heart function within minutes of a single exposure, according to a new study by the University of Guelph in Ontario and published in the journal Scientific Reports.

The study entailed treating mouse hearts with BPA and BPS at levels typically seen in people. Each chemical on its own was found to depress heart function by dampening heart contractions causing slower blood flow. However, BPS had a quicker impact, within five minutes of exposure. When mice were given bisphenol BPA or BPS in amounts that mimicked typical human levels, their heart function worsened, especially in females, within minutes of exposure.

These findings are concerning, as endocrine receptors and metabolic pathways are similar in mice and humans, according to Glen Pyle, PhD, lead author of the study and biomedical sciences professor. The study raises concerns about the safety of BPS as a replacement for BPA. It's particularly worrisome for people with coronary heart disease, high blood pressure, diabetes or obesity, because the effects of BPS could increase the chance of a heart attack or make a heart attack more severe.

BPA is found in plastics used for food packaging, including liners for metal cans and other containers, as well as in medical devices such as hospital intravenous lines and dental sealants. The European Union and Canada have banned BPA use in baby bottles, though the U.S. still allows BPA in food contact applications. However, some manufactures are using BPS as a replacement in their products and labelling them as BPA-free.

Although the body gets rid of bisphenols quickly, their ubiquitous use in so many consumer goods means that the substance persists.

Pyle advocates banning the substitute chemical BPS from such consumer products as food and beverage packaging, toys and thermal paper receipts. He also suggests consumers reduce plastic use, including single-use plastics.

"Previous research has looked at the chronic effects that can happen when exposed to BPS over days," said Pyle. "But we are the first to show how fast BPS can work. This is an important finding because it means you don't need to have a buildup of the chemical over time to experience its harmful effects."